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Clinical Chemistry Unit

   One of the main units of Clinical Pathology Department, Faculty of Medicine, Mansoura University. The research and teaching places are located in the first floor of the main buildings of faculty of Medicine and Mansoura University Hospital. Besides, laboratories performing special testing profiles located in all specialized medical centers of Mansoura university: Mansoura university main hospital, Gastroenterology center, Emergency hospital, Pediatric hospital, Oncology center, Ophthalmology center and Special medicine hospital. Laboratory work in all these is run on a 24- hour basis, for in – and out- patients. The unit was founded in 1978 by Prof. Mohamed Hassan Al- Kannishy as a single laboratory performing routine lab. testing and has grown rapidly though personnel, work area, number of laboratories, equipment etc… The unit was headed by Prof. Mohamed Hassan Al- Kannishy up to 1991 then Prof. Ekbal Mohamed Abo Hashem, starting 1991 up till 2008 after that  Prof. Nawal Abd Al Galil Ghareeb from 2008 to 2009 and Prof. Kefaya Al-Saied Mohamed from 2009 up till now.
The members of the unit are:

Prof. Mohamed Hassan Al- Kannishy

Prof. Ekbal Mohamed Abo Hashem

Prof. Nawal Abd Al Galil Ghareeb

Prof. Kefaya Al- Saied Mohamed

Prof. Hamdy Fouad

Prof . Hosam Ahmed Ghanem

Prof . Mohamed Aly Atwa

Prof. Mohamed Al-Arman

Prof. Azza Abd Al-Baky Al- Bayomi

Ass. Prof. Amany Ragab

Ass. Prof.  Abeer Mesbah

Ass. Prof. Ibrahim Abd Al Aal

Dr. Reham Al Farahaty (lecturer)

Sahar Abd Al-Gawad  (Assistant lecturer)

Dr. Sahar Al-Saied (lecturer)

Dr. Mana Abo Bakr (lecturer)

Ehsan Abd-El Aty (lecturer)

Hodea Al Shony (Assistant lecturer)

Rasha Rizk Abass Al-Zehary (Assistant lecturer)

Ranya Mostafa Abd Al-Latef (Assistant lecturer)

Nermeen Mohamed Mohamed Kady (Assistant lecturer)

Ola Al-Emam (Assistant lecturer)

Nansy Mahsob (Assistant lecturer)

Narmen Efat (Assistant lecturer)

Dalia Tohlob (Assistant lecturer)

Laboratory technicians               ( 25  )

Instrument technicians               ( 2  )

Secretaries                                ( 9 )


Different laboratories perform routine testing for: -

Diabetic panel: glucose and HbA1c.
Liver function tests: ALT, AST, Bilirubin, Albumin  Alk. Phosphatase, GGT.
Kidney function tests: creatinine, BUN, Uric acid, creatinine clearance, Urine analysis.
Plasma protein separation by electrophoresis.
Investigations for cardiac, gastro- intestinal function.
Bone panel: Ca, Ph, ALP, PTH, Osteocalcin, b cross lap.
Examination of body fluids: CSF- ascetic - pleural- synovial and semen analysis.
Investigations for endocrinal disorders (Pituitary-thyroid-parathyroid-suprarenal-gonads-infertility work up).
Investigations for early diagnosis and monitoring of malignant disease – tumor markers (CA15-3-CEA-AFP-CA19-9-CA125, PSA).
Blood gases and electrolyte measurements
A fully equipped research laboratory carries out:
Specialized, fine and sophisticated laboratory work- up, serving MD and MSc thesis for post graduates, and post- doctoral researchers from all universities, and in different fields of research interest.
Clinical Chemistry Unit participated in research projects incorporation with the following Universities:  


Biochemical tumor markers and risk factors of hepatocellular carcinoma.
Diagnostic and predictive biochemical markers for polytraumatized patients.

The unit also participating in three research projects funded by Mansoura University Research project. These projects are:
1- ERASMUS University, Dkjight University hospital, Rotterdam, The Netherlands with the following international publications:


Suramin prevents ACTH-stimulated adrenocortical cells in rats (J. Endocrinology)
Effect of Suramin on pituitary secretagogues (J. Clin. End. Metabolism)
The effect of chlorimpramine on cultured active pituitary cells (J. Clin. End. Metabolism)
Caffeine enhances the speed of hypothalamo-pituitary-adrenal axis recovery after prolonged intake of pridnisoline (Neuroendocrinology)
The effect of CS 69865 on human adrenal gland (J. Endocrinology)

Equipments include: -

Ultracentrifuge (Programmable).
Gamma Counter.
Automated electro-chemiluminescence analyzer.
Automated chemiluminescence analyzer.
Automated chemistry analyzer.
ELISA system.
Blood gas analyzer.
Electrolyte analyzer.
Electrophoresis system.
Scanner for electrophoretic strips.
Cooling programmable centrifuge.
PH meter
Water Distiller.
Deep freezer -80oC. 

Research interest:

Molecular clinical chemistry.
Oxidative stress, cytoprotective enzymes (role in different disease).
Lipid research: lipid fractionation by electrophoresis, ultracentrifugation, lipid peroxides, leptins.
Growth factors and cytokines.
Tumorigenesis, use of tumor markers in diagnosis and monitoring.
Hypertension, atherogenesis, evaluation of cardiac risk.
Bone specific markers.
Reproductive chemistry, fertility studies and antenatal screening.
Vasoactive substances and adhesion molecules.
Biochemical markers of ischemia reperfusion injuries.
Biochemical tumor markers and risk factors of hepatocellular carcinoma.
Diagnostic and predictive biochemical markers for polytraumatized patients.

Teaching Courses 

1- For Ms of Subsidiaries:

Diabetic lab. pannel
Pancreatic & gastric Function  tests,
Body Fluids
Liver Function tests
Kidney Function tests
Cardiac markers
Tumor markers
Hypothalamo-Pituitary-thyroid function tests.
Hypothalamo-Pituitary-adrenal function tests.

2- For Ms and MD of Clinical Pathology:

Academic Courses:

ِِ Analytical quality management

Pre and post analytical Q.M

Evaluation of tumor markers

Tumor marker: Types and significance

Liver function and Bilirubin disorders

Laboratory assessment of liver functions

Assessment of Bone and Mineral metabolic disorders (calcium)

Phosphorus and Magnesium Clinical Significance.

Laboratory assessment of cardiac function

Gastric function Tests

Carbohydrate metabolic disorders

Laboratory assessment of D.M

Female reproductive organ disorders

Male Reproductive organ disorders

Clinical chemistry of serous fluid

Clinical significance of CSF and semen analysis

Acid base balance

ٌ Relevant disorders of acid base balance

Thyroid Function tests

Assessment of thyroid disorders

Hypothalamic and pituitary Hormones

Assessment of Hypothalamic- pituitary function

Adrenocortical Functions

Adreno-medullary Function tests

Clinical enzymology(Classification homeostasis and Kinetic)

Enzymes in clinical diagnosis

Pancreatic Function test

Malabsorption Syndrome

Lipid metabolism and Lipoproteins abnormalities

Metabolic Syndrome Laboratory assessment

Clinical Chemistry of Pregnancy

ِ Assessment of Fetoplacental integrity

Inborn Errors of Metabolism

Laboratory assessment (A.A, organic ,F.A, glucose, mucopolysaccharides and others)
Screening For Metabolic Inborn Errors.

Clinical Chemistry of Geriatric

Clinical Chemistry of pediatric

Oxidant and Antioxidants
Vitamins, Trace elements)

Laboratory assessment of nutritional status and obesity

Kidney function pathophysiology

Renal function tests

Protein metabolism : Clinical significance of carrier proteins

Acute Phase reactants in disease diagnosis

Molecular biology Techniques

Molecular biology in disease diagnosis

Pancreatic Hormones Pathophysiology

Pancreatic Hormones in Clinical diagnosis

Electrolyte disorder

Dehydration Versus SIADH

Drug monitoring

Drug abuse

Practical Courses:
1) Case study:

Lab assessment of D.M.

Reproductive disorders

Body fluids

Acid base balance

Thyroid function

Hypothalamic pituitary axis disordes


2) Instrument and analytical techniques:



Electrochemical Techniques

Immunochemical Techniques


Automation in Clinical Chemistry

Quality Management

Kinetic assay

Protein Curve

Assay of Creatinine, Uric acid and BUN.

Assay of Bilirubin

Assay of Glucose

Lipid assay